coumarins could be synthesized with many different methods like Perkin reaction, Knoevenagel condensation,
Pechmann condensation, Wittig reaction, Baylis-Hillman reaction,
Claisen rearrangement and Vilsmeier-Haack and Suzuki cross-coupling reaction
Coumarin is prepared by treating the sodium salt of ortho-hydroxybenzqaldehyde with acetic anhydride. It involves other methods which have been developed by Pechmann Claisen, Knoevenagal, Reformatsky reaction and Wittig for the synthesis of pyrone-ring moieties in coumarins.
Coumarins are commonly used in the treatment of prostate cancer, renal cell carcinoma and leukemia, and they also have the ability to counteract the side effects caused by radiotherapy. Both natural and synthetic coumarin derivatives draw attention due to their photochemotherapy and therapeutic applications in cancer.
coumarin was well tolerated at the applied doses (600–5000 mgs)